Detailed view for TVAG_117470

Basic information

TDR Targets ID: 887740
Trichomonas vaginalis, protein disulfide isomerase, putative
Source Database / ID: 

pI: 5.3589 | Length (AA): 372 | MW (Da): 41287 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00085   Thioredoxin
PF07749   Endoplasmic reticulum protein ERp29, C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005783   endoplasmic reticulum  
GO:0045454   cell redox homeostasis  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127741)

Species Accession Gene Product
Arabidopsis thaliana AT2G47470   protein disulfide-isomerase like 2-1
Arabidopsis thaliana AT2G32920   protein disulfide-isomerase like 2-3
Arabidopsis thaliana AT1G04980   protein disulfide-isomerase like 2-2
Babesia bovis BBOV_IV009100   protein disulfide isomerase related protein
Brugia malayi Bm1_33495   Probable protein disulfide isomerase A6 precursor, putative
Candida albicans CaO19.2516   similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase
Candida albicans CaO19.10052   similar to N terminus of S. pombe SPAC17H9.14c putative protein disulfide isomerase
Caenorhabditis elegans CELE_B0403.4   Protein TAG-320
Caenorhabditis elegans CELE_Y49E10.4   Protein Y49E10.4
Cryptosporidium hominis Chro.70453   protein disulfide isomerase-related protein (provisional)
Cryptosporidium parvum cgd7_4080   protein disulfide isomerase, signal peptide, ER retention motif
Dictyostelium discoideum DDB_G0276141   protein disulfide isomerase
Drosophila melanogaster Dmel_CG5809   calcium-binding protein 1
Echinococcus granulosus EgrG_001002700   protein disulfide isomerase A6
Entamoeba histolytica EHI_071590   protein disulfide isomerase, putative
Echinococcus multilocularis EmuJ_001002700   protein disulfide isomerase A6
Homo sapiens ENSG00000143870   protein disulfide isomerase family A, member 6
Leishmania braziliensis LbrM.26.0670   protein disulfide isomerase, putative
Leishmania donovani LdBPK_260630.1   protein disulfide isomerase, putative
Leishmania infantum LinJ.26.0630   protein disulfide isomerase, putative
Leishmania major LmjF.26.0660   protein disulfide isomerase, putative
Leishmania mexicana LmxM.26.0660   protein disulfide isomerase, putative
Loa Loa (eye worm) LOAG_02996   TAG-320 protein
Mus musculus ENSMUSG00000020571   protein disulfide isomerase associated 6
Neospora caninum NCLIV_065470   hypothetical protein
Oryza sativa 4326806   Os01g0339900
Oryza sativa 4337858   Os05g0156300
Oryza sativa 4347226   Os09g0451500
Plasmodium berghei PBANKA_0914300   protein disulfide isomerase related protein, putative
Plasmodium falciparum PF3D7_1134100   protein disulfide isomerase
Plasmodium knowlesi PKNH_0932300   protein disulfide-isomerase, putative
Plasmodium vivax PVX_092315   protein disulfide isomerase, putative
Plasmodium yoelii PY06980   Thioredoxin, putative
Schistosoma japonicum Sjp_0207350   ko:K01829 protein disulfide-isomerase [EC5.3.4.1], putative
Schistosoma mansoni Smp_172110   shc transforming protein
Schmidtea mediterranea mk4.001731.00   Protein disulfide-isomerase A6
Schmidtea mediterranea mk4.003196.02  
Trypanosoma brucei gambiense Tbg972.7.1260   protein disulfide isomerase, putative
Trypanosoma brucei Tb927.7.1300   protein disulfide isomerase, putative
Trypanosoma congolense TcIL3000_7_920   protein disulfide isomerase, putative
Trypanosoma cruzi TcCLB.508209.140   protein disulfide isomerase, putative
Trypanosoma cruzi TcCLB.509505.10   protein disulfide isomerase, putative
Toxoplasma gondii TGME49_249270   protein disulfide isomerase-related protein (provisional), putative
Theileria parva TP01_0863   protein disulfide isomerase, putative
Trichomonas vaginalis TVAG_277120   protein disulfide isomerase, putative
Trichomonas vaginalis TVAG_117470   protein disulfide isomerase, putative

Essentiality

TVAG_117470 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.1300 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.1300 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.1300 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.1300 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0403.4 Caenorhabditis elegans larval arrest wormbase
TGME49_249270 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein disulfide isomerase family A, member 6 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TVAG_117470 (Trichomonas vaginalis), protein disulfide isomerase, putative
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